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Subject - Chemistry:

Basics

MCQ - 239-2425

Question:

Which of the following statements best describes structure-activity relationships (SAR)?

  1. The study of which functional groups are important to the chemical reactivity of the drug.
  2. The study of the physicochemical properties that are important to the absorption of a drug into the blood supply.
  3. The study of the structural features of a drug that are important to its biological activity.
  4. The study of the physicochemical properties that are important to the absorption of a drug into the blood supply.

Correct Answer: C

Explanation:

The study of the structural features of a drug that are important to its biological activity. Structure-activity relationships involve the synthesis of a series of analogues of a lead compound to discover how changes in structure affect the biological activity. In this way, important binding groups and the drug's pharmacophore can be identified.

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