Correct Answer: B
Explanation:
The first clause of this sentence, "How many times do I have to tell you," is actually a rhetorical question. It is an independent clause and therefore must be separated with stronger punctuation than just a comma. In this case, it would be appropriate to set it off as its own sentence, ending in a question mark, but regardless, the comma splice in "you, you" is what makes this sentence ungrammatical.